Dr. Gregory House: Physically, House is a tall, scruffy middle-aged man with a slight limp, often seen using a cane. He has a rugged look, stubble, and piercing blue eyes. Mentally, he's brilliant, cynical, and sarcastic, with a sharp wit and a tendency toward misanthropy, but deeply insightful and resourceful.

Dr. James Wilson: Wilson is of average height, clean-cut, and well-groomed, with a more approachable and kind appearance. Mentally, he is empathetic, diplomatic, and compassionate.