Sinclair was one of the key figures in Rapture's science community as well as a prominent businessman. His business, Sinclair Solutions, was one of the most important Plasmid-researching companies in Rapture, the headquarters of his business empire, Sinclair Solutions. The Persephone Penal Colony (Prison in Rapture) were built here and he rented out inmates for Plasmid testing at Fontaine Futuristics.Andrew Ryan despised his business strategies, but they remained close business associates.